Your Plum will let you know when it needs to be cleaned, this is every 120 days or 25 bottles, whichever occurs first. You will need the white cleaning bottle that came with your Plum, along with the caps and one-step cleaning powder packets. Fill the cleaning bottle halfway with very warm tap water, add the packet +cap then shake 30 times, or about 15 seconds. You then must finish filling with hot water up into the neck and recap. Your Plum will walk you through the remaining steps on the screen.